:root {
  color-scheme: light;
  --ink: #172c22;
  --muted: #626e66;
  --green: #205540;
  --line: #dcded2;
  --paper: #f4f1e8;
  --panel: #fffdf7;
  --coral: #cd745e;
  font-family: "Avenir Next", Avenir, ui-sans-serif, -apple-system, BlinkMacSystemFont, "Segoe UI", sans-serif;
  color: var(--ink);
  background: var(--paper);
  font-synthesis: none;
}
* { box-sizing: border-box; }
body { margin: 0; min-width: 320px; background: radial-gradient(ellipse at 90% 0%, #dce9de, transparent 620px), var(--paper); }
a { color: var(--green); text-underline-offset: 4px; }
button, input, select, textarea { font: inherit; }
main { max-width: 1220px; margin: auto; padding: 0 32px 24px; }

.hero { display: grid; grid-template-columns: minmax(0,1fr) 440px; align-items: center; gap: 48px; padding: 38px 0 32px; }
.wordmark { margin: 0 0 18px; color: var(--green); font-size: 18px; font-weight: 650; line-height: 1; letter-spacing: .12em; }
h1 { margin: 0; max-width: 650px; font-size: clamp(32px,3.4vw,43px); font-weight: 500; line-height: 1.16; letter-spacing: -.035em; text-wrap: balance; }
.intro { max-width: 510px; margin: 18px 0 0; color: var(--muted); font-size: 15px; line-height: 1.7; text-wrap: pretty; }
.resource-links { display: flex; flex-wrap: wrap; gap: 7px; margin-top: 12px; }
.resource-links a { display: inline-flex; align-items: center; justify-content: center; gap: 6px; min-height: 36px; padding: 8px 12px; border: 1px solid #aabbaa; border-radius: 6px; background: #fffdf7; box-shadow: 0 2px 0 #dce2d5; color: var(--green); font-size: 11px; line-height: 1.4; font-weight: 600; text-decoration: none; }
.resource-links a:hover { background: #e7eee9; border-color: var(--green); }.resource-links a:active { box-shadow: none; transform: translateY(1px); }

.example-button { display: inline-flex; align-items: center; justify-content: space-between; gap: 12px; width: max-content; max-width: 100%; min-height: 42px; margin-top: 22px; padding: 8px 13px; border-color: #aabbaa; border-radius: 6px; background: #e7eee9; box-shadow: 0 2px 0 #dce2d5; color: var(--green); font-size: 13px; line-height: 1.3; text-align: left; }
.example-button:hover:not(:disabled) { border-color: var(--green); background: #dce9df; }
.example-button:active:not(:disabled) { box-shadow: none; transform: translateY(1px); }

.genetics-figure { width: 100%; max-width: 440px; justify-self: end; margin: 0; padding: 10px 8px; min-width: 0; border: 1px solid #c8d6c9; border-radius: 10px; background: linear-gradient(135deg, #fffdf7b3, #e8eee1b3); }
.genetics-figure { transform: rotate(1deg); box-shadow: 0 20px 50px #174f3d1a; }
.genetics-figure:hover, .genetics-figure:focus-within { border-color: #8eae9a; box-shadow: 0 25px 60px #174f3d2b; }
.genetics-figure svg { display: block; width: 100%; height: auto; }
.plot-title { fill: var(--green); font-size: 13px; font-weight: 600; }
.plot-grid { fill: none; stroke: #dce2d5; stroke-width: .7; }
.plot-axis { fill: none; stroke: #9aa995; stroke-width: .8; }
.plot-ticks { fill: var(--muted); font-size: 9px; font-variant-numeric: tabular-nums; }
.axis-label { fill: var(--muted); font-size: 10px; }
.significant-hits { fill: #c36045; }
.significance-line { fill: none; stroke: #c36045; stroke-width: .65; stroke-dasharray: 3 3; opacity: .6; }
.significance-label, .threshold-label { fill: #a34c35; font-size: 9px; }
.scoring-arrow { fill: none; stroke: #8ba38b; stroke-width: 1.2; stroke-linecap: round; stroke-linejoin: round; }
.prs-area { fill: #dce8d8; }.prs-tail { fill: #e7b6a0; }
.prs-curve { fill: none; stroke: var(--green); stroke-width: 1.8; }
.prs-threshold { fill: none; stroke: #b65e43; stroke-width: 1.2; stroke-dasharray: 3 3; }
.genetics-figure figcaption { display: flex; justify-content: space-between; flex-wrap: wrap; gap: 3px 16px; margin: 2px 8px 0; padding-top: 8px; border-top: 1px solid #d1dacb; color: var(--muted); font-size: 9px; line-height: 1.5; }
.genetics-figure figcaption span { font-size: 9px; }

.workspace { display: grid; grid-template-columns: minmax(0,1fr); gap: 24px; }
.configuration-panels { display: grid; grid-template-columns: minmax(0,1fr) minmax(0,1fr); grid-template-areas: "sumstats ld" "model model"; gap: 24px; align-items: stretch; }
.configuration-panels > .card { min-width: 0; margin-bottom: 0; }
.configuration-panels > .sumstats-card { grid-area: sumstats; }
.configuration-panels > .ld-card { grid-area: ld; }
.model-card { grid-area: model; display: grid; grid-template-columns: minmax(280px,.92fr) minmax(380px,1.08fr); column-gap: 0; align-items: start; }
.model-card > .section-heading { grid-column: 1 / -1; }
.model-settings { min-width: 0; padding-right: 34px; }
.hosted-source-card { margin-top: 18px; padding: 20px; border: 1px solid #c8d9cf; border-radius: 15px; background: #f8fbf8; }
.hosted-heading { display: flex; align-items: center; justify-content: space-between; flex-wrap: wrap; gap: 10px; font-size: 13px; }
.source-badge { padding: 5px 8px; border: 1px solid #bad8c8; border-radius: 999px; background: #edf5f0; color: var(--green); font: 500 9px ui-monospace, monospace; white-space: nowrap; }
.hosted-path { display: block; padding: 12px; border: 1px solid #c8d9cf; border-radius: 7px; background: #e8f0eb; color: var(--green); font: 12px/1.7 ui-monospace, monospace; overflow-wrap: anywhere; }
.reference-details { margin-top: 15px; padding-top: 13px; border-top: 1px solid #d8e2dc; }
.card { margin-bottom: 18px; padding: 26px 28px; background: var(--panel); border: 1px solid var(--line); border-radius: 12px; }
fieldset { min-width: 0; margin: 0; padding: 0; border: 0; }
h2 { margin: 0; font-size: 18px; font-weight: 600; letter-spacing: -.025em; }
.section-heading { display: flex; align-items: center; justify-content: space-between; gap: 18px; margin-bottom: 20px; }
.panel-title { display: flex; align-items: center; gap: 11px; }
.panel-icon { flex: 0 0 21px; width: 21px; height: 21px; fill: none; stroke: #526e5b; stroke-width: 1.5; stroke-linecap: round; stroke-linejoin: round; }
label { display: block; margin: 17px 0 7px; font-size: 12px; font-weight: 600; }
input, select, textarea { width: 100%; min-height: 44px; padding: 10px 12px; border: 1px solid #cdd4c8; border-radius: 7px; outline: none; background: #fffefa; color: var(--ink); font-size: 13px; line-height: 1.4; }
input:hover, select:hover, textarea:hover { border-color: #96ac9a; }
input:focus, select:focus, textarea:focus { border-color: var(--green); box-shadow: 0 0 0 3px #20554014; }
textarea { resize: vertical; line-height: 1.55; }
input:disabled, select:disabled { color: var(--muted); background: #f0f1e9; }
select { appearance: none; -webkit-appearance: none; padding-right: 38px; background-image: url("data:image/svg+xml,%3Csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 16 16'%3E%3Cpath d='m4 6 4 4 4-4' fill='none' stroke='%23526e5b' stroke-width='1.5' stroke-linecap='round' stroke-linejoin='round'/%3E%3C/svg%3E"); background-repeat: no-repeat; background-position: right 12px center; background-size: 16px 16px; }
select:disabled { background-color: #f0f1e9; background-image: none; }
input[type=file] { padding: 8px; font-size: 12px; }
input::file-selector-button { margin-right: 10px; padding: 7px 10px; cursor: pointer; border: 0; border-radius: 4px; background: #e8eee3; color: var(--ink); font: inherit; }
input::placeholder, textarea::placeholder { color: #778477; }
.hint { margin: 8px 0 0; color: var(--muted); font-size: 11px; line-height: 1.65; }
.notice { margin: 16px 0; padding: 15px; border: 1px solid #dfc993; border-radius: 6px; background: #fffaf0; color: #715421; font-size: 12px; line-height: 1.6; }
.example-box { display: grid; grid-template-columns: 32px 1fr auto; align-items: center; gap: 12px; margin-top: 14px; padding: 15px; border-radius: 7px; background: #eaf0e5; }
.chromosome { display: grid; place-items: center; width: 30px; height: 36px; border-radius: 14px; background: #d4e2d2; color: var(--green); }
.chromosome i { display: none; }.chromosome b { font: 600 11px ui-monospace,monospace; }
.example-copy { min-width: 0; }.example-copy strong { display: block; font-size: 12px; }.example-copy span { display: block; margin-top: 4px; color: var(--muted); font-size: 10px; line-height: 1.5; }
.example-links { display: flex; gap: 10px; font-size: 10px; }.example-links a { font-weight: 600; text-decoration: none; }
.selection-summary { color: var(--green); font-size: 11px; }
.data-rule { margin: 14px 0 0; color: var(--muted); font-size: 11px; line-height: 1.6; }
.prior-figure { align-self: stretch; min-width: 0; margin: 0; padding: 14px 0 0 34px; border-left: 1px solid var(--line); }
.prior-figure-heading { display: flex; align-items: center; justify-content: space-between; flex-wrap: wrap; gap: 8px 18px; }
.prior-figure-heading > div { display: grid; gap: 4px; }
.prior-figure-heading strong { font-size: 14px; font-weight: 600; letter-spacing: -.015em; }
.preview-label { color: var(--green); font: 600 9px ui-monospace, SFMono-Regular, monospace; letter-spacing: .1em; text-transform: uppercase; }
.prior-figure-heading output { padding: 5px 8px; border: 1px solid #d4dfd2; border-radius: 999px; background: #f1f5ed; color: var(--green); font: 10px ui-monospace, SFMono-Regular, monospace; white-space: nowrap; }
.prior-figure-copy { margin: 8px 0 12px; color: var(--muted); font-size: 10px; line-height: 1.55; }
.prior-figure svg { display: block; width: 100%; height: 150px; overflow: visible; border: 1px solid #dde4da; border-radius: 8px; background: linear-gradient(180deg, #fbfcf8, #f6f8f2); }
.prior-grid { fill: none; stroke: #e3e8df; stroke-width: 1; }
.prior-axis { fill: none; stroke: #89978b; stroke-width: 1; }
.slab-curve { fill-opacity: .1; stroke-width: 2; stroke-linejoin: round; }
.spike-mark path { fill: none; stroke: #b23a2b; stroke-width: 2.2; }
.spike-mark circle { fill: #b23a2b; }
.prior-ticks { fill: var(--muted); stroke: #89978b; stroke-width: 1; font-size: 10px; }
.prior-ticks text { stroke: none; }
.prior-figure figcaption { display: flex; flex-wrap: wrap; gap: 6px 18px; margin-top: 10px; color: var(--muted); font-size: 9px; line-height: 1.5; }
.prior-figure figcaption span { display: inline-flex; align-items: center; gap: 6px; }
.prior-figure figcaption i { display: inline-block; flex: 0 0 auto; width: 14px; }
.spike-legend { color: #9f3024; }.slab-legend { color: #185f87; }
.key-spike { height: 12px; border-left: 2px solid #b23a2b; }
.key-slab { height: 7px; border-top: 2px solid #1f6f9c; border-radius: 50%; }
.two-columns { display: grid; grid-template-columns: 1fr 1fr; gap: 0 16px; }
.advanced { margin-top: 20px; padding-top: 15px; border-top: 1px solid var(--line); }
summary { cursor: pointer; color: var(--muted); font-size: 12px; font-weight: 500; }
button, .button { display: inline-flex; align-items: center; justify-content: center; gap: 14px; cursor: pointer; border: 1px solid #cdd4c8; border-radius: 7px; background: var(--panel); color: var(--ink); font-size: 12px; font-weight: 600; padding: 12px 16px; text-decoration: none; }
button:hover:not(:disabled), .button:hover { background: #eaf0e5; }
button:disabled { cursor: not-allowed; opacity: .48; }
.text-button { border: 0; background: transparent; color: var(--green); font-size: 11px; padding: 4px 0; }
.text-button:hover:not(:disabled) { background: transparent; text-decoration: underline; text-underline-offset: 4px; }
.actions { display: flex; gap: 10px; }.primary { min-height: 48px; min-width: 210px; border-color: var(--green); background: var(--green); color: white; font-size: 13px; }.primary:hover:not(:disabled) { background: #153f2e; }
.privacy { display: flex; align-items: center; gap: 7px; margin: 12px 0 0; color: var(--muted); font-size: 10px; line-height: 1.6; }
.privacy svg { flex: 0 0 13px; width: 13px; height: 13px; fill: none; stroke: currentColor; stroke-width: 1.2; }

.monitor { overflow: hidden; margin-bottom: 0; display: grid; grid-template-columns: minmax(0,1fr) auto; column-gap: 32px; align-items: center; border-color: #c5d3bf; background: linear-gradient(110deg, #f8fbf3, var(--panel) 65%); }
.monitor > .section-heading, .monitor > .activity-details, .monitor > .timing-summary { grid-column: 1 / -1; }
.monitor > .section-heading { margin-bottom: 22px; }
.monitor > .actions { grid-column: 2; grid-row: 2; }
.monitor > .privacy { grid-column: 1 / -1; margin: 0 0 20px; }
.monitor > .runtime-area { grid-column: 1 / -1; border-top: 1px solid var(--line); padding: 12px 0; }
.monitor > .metrics { grid-column: 1 / -1; }
.status { padding: 6px 9px; border: 1px solid #d5e0ce; border-radius: 5px; background: #edf3e7; color: var(--green); font-size: 10px; font-weight: 600; text-transform: uppercase; letter-spacing: .06em; }
.status::before { content: ""; display: inline-block; width: 6px; height: 6px; margin-right: 6px; border-radius: 50%; background: #508365; }.status[data-state=error] { color: #a83f30; }.status[data-state=error]::before { background: #a83f30; }
.run-placeholder { display: flex; align-items: center; gap: 16px; padding: 0 0 20px; text-align: left; }
.activity { position: relative; flex: 0 0 44px; width: 44px; height: 44px; border-radius: 50%; background: #e5eede; }
.activity::after { content: ""; position: absolute; left: 18px; top: 15px; border-left: 10px solid var(--green); border-top: 7px solid transparent; border-bottom: 7px solid transparent; }
.activity span { display: none; }
.activity.running::after { display: none; }.activity.running span:first-child { display: block; position: absolute; inset: 10px; border: 2px solid #bed0b6; border-top-color: var(--green); border-radius: 50%; }
.activity[data-state=converged]::after, .activity[data-state=iteration-limit]::after { width: 13px; height: 7px; left: 15px; top: 16px; border: 0; border-left: 2px solid var(--green); border-bottom: 2px solid var(--green); transform: rotate(-45deg); }
.run-placeholder h3 { margin: 0 0 8px; font-size: 15px; font-weight: 600; }
#status { margin: 0; color: var(--muted); font-size: 12px; line-height: 1.65; overflow-wrap: anywhere; }
.elapsed-line { margin: 16px 0 0; color: var(--muted); font-size: 11px; }.elapsed-line span { margin-left: 5px; color: var(--ink); font-variant-numeric: tabular-nums; font-weight: 600; }
.metrics { display: grid; grid-template-columns: 1.25fr 1fr 1fr; gap: 12px; padding: 18px 0; border-top: 1px solid var(--line); }
.metrics span { display: block; color: var(--muted); font-size: 9px; text-transform: uppercase; letter-spacing: .06em; }.metrics strong { display: block; margin-top: 6px; font-size: 23px; font-weight: 600; font-variant-numeric: tabular-nums; }
.timing-summary { margin: 0; padding: 12px 0 17px; border-top: 1px solid var(--line); color: var(--muted); font-size: 11px; line-height: 1.6; }
.runtime-area { display: flex; align-items: center; justify-content: space-between; gap: 10px; padding: 15px 0; border-top: 1px solid var(--line); font-size: 11px; }
.runtime-state { display: inline-flex; align-items: center; gap: 8px; color: var(--muted); }
.runtime-dot { flex: 0 0 6px; width: 6px; height: 6px; border-radius: 50%; background: #bd8b36; }
.runtime-state[data-state=ready] .runtime-dot { background: #508365; }.runtime-state[data-state=error] .runtime-dot { background: #a83f30; }
.activity-details { padding-top: 15px; border-top: 1px solid var(--line); }
pre { max-height: 190px; overflow: auto; margin: 12px 0 0; padding: 12px; border-radius: 4px; background: #f0f1e9; color: var(--muted); font: 10px/1.7 ui-monospace,SFMono-Regular,monospace; white-space: pre-wrap; overflow-wrap: anywhere; }

.results { margin-top: 28px; padding: 30px; }.results-heading { align-items: flex-end; }.section-kicker { margin: 0 0 6px; color: var(--green); font-size: 10px; font-weight: 600; letter-spacing: .1em; text-transform: uppercase; }
.downloads { display: flex; gap: 8px; flex-wrap: wrap; }.downloads .button { padding: 10px 13px; font-size: 11px; }
.result-summary { margin: -5px 0 0; color: var(--muted); font-size: 12px; line-height: 1.6; }
.result-toolbar { display: flex; align-items: center; flex-wrap: wrap; gap: 10px; margin-top: 23px; }.result-toolbar label { margin: 0; }.result-toolbar select { width: auto; min-height: 36px; padding: 7px 38px 7px 11px; font-size: 12px; }.result-toolbar .hint { margin: 0 0 0 auto; }
.table-scroll { overflow: auto; max-height: 560px; margin-top: 18px; }
table { width: 100%; border-collapse: collapse; text-align: left; }
th { position: sticky; top: 0; z-index: 1; padding: 11px 13px; border-bottom: 1px solid var(--ink); background: var(--panel); color: var(--muted); font: 500 11px ui-monospace, SFMono-Regular, monospace; letter-spacing: .06em; text-transform: uppercase; }
td { padding: 12px 13px; border-bottom: 1px solid var(--line); font-size: 13px; }td, th { white-space: nowrap; }td:first-child, td:nth-child(2), td:nth-child(n+5) { font: 12px ui-monospace, SFMono-Regular, monospace; font-variant-numeric: tabular-nums; }td:nth-child(n+5), th:nth-child(n+5) { text-align: right; }
tbody tr:hover { background: #eef3ed; }
.table-note { margin: 14px 0 0; color: var(--muted); font: 11px/1.7 ui-monospace, monospace; }
footer { margin-top: 36px; padding: 24px 16px 18px; border-top: 1px solid var(--line); color: var(--muted); font: 11px/1.9 ui-monospace, monospace; text-align: center; }footer p { margin: 5px 0; }footer a { text-decoration: none; }footer a:hover { text-decoration: underline; }
[hidden] { display: none !important; }:focus-visible { outline: 3px solid #61967880; outline-offset: 3px; }
@keyframes threshold-sway {
  0%, 100% { transform: translateX(0); }
  25% { transform: translateX(-8px); }
  75% { transform: translateX(8px); }
}
@media (prefers-reduced-motion: no-preference) and (hover: hover) {
  .prs-threshold, .threshold-label, #tail-window { animation: threshold-sway 5s ease-in-out infinite; animation-play-state: paused; }
  .genetics-figure:hover .prs-threshold, .genetics-figure:hover .threshold-label, .genetics-figure:hover #tail-window { animation-play-state: running; }
}
@keyframes rotate { to { transform: rotate(360deg); } }
@media (prefers-reduced-motion: no-preference) { .genetics-figure { transition: box-shadow .25s, border-color .25s, transform .25s; }.genetics-figure:hover, .genetics-figure:focus-within { transform: rotate(.3deg) translateY(-2px); } .activity.running span:first-child { animation: rotate 1.25s linear infinite; }.activity.running span:nth-child(2) { animation: rotate 1.8s linear infinite reverse; }button, a, input, select, textarea { transition: border-color .15s,color .15s,background .15s; } }
@media (max-width: 1000px) {
  .hero { gap: 28px; grid-template-columns: minmax(0,1fr) 380px; }
  .configuration-panels { gap: 18px; }
  .model-card { grid-template-columns: minmax(250px,.88fr) minmax(340px,1.12fr); }
  .model-settings { padding-right: 26px; }
  .prior-figure { padding-left: 26px; }
  .card { padding: 22px; }.example-box { grid-template-columns: 30px 1fr; }.example-links { grid-column: 2; }
}
@media (max-width: 760px) {
  .hero { padding-top: 36px; grid-template-columns: 1fr; gap: 28px; }.hero-copy { max-width: 600px; }
  .genetics-figure { max-width: 480px; justify-self: center; }
  .configuration-panels { grid-template-columns: 1fr; grid-template-areas: "sumstats" "ld" "model"; gap: 18px; }
  .model-card { display: block; }.model-settings { padding-right: 0; }.model-card .prior-figure { margin-top: 22px; padding: 22px 0 0; border-top: 1px solid var(--line); border-left: 0; }
  .monitor { grid-template-columns: minmax(0,1fr); }
  .monitor > .actions { grid-column: 1; grid-row: auto; margin-bottom: 16px; }.monitor > .runtime-area { grid-column: 1; grid-row: auto; justify-content: space-between; }
}
@media (max-width: 480px) {
  main { padding: 0 17px 20px; }h1 { font-size: 32px; }.intro { font-size: 14px; }.wordmark { font-size: 16px; margin-bottom: 16px; }
  .hero { padding-bottom: 28px; }.genetics-figure { padding: 14px 8px 12px; }
  .card { padding: 21px 18px; }.two-columns { grid-template-columns: 1fr; }.privacy { align-items: flex-start; }.privacy svg { margin-top: 2px; }
  .primary { min-width: 0; flex: 1; }.run-placeholder { gap: 16px; }.monitor { column-gap: 0; }
  .results { padding: 22px 18px; }.results-heading { flex-direction: column; align-items: stretch; }.downloads .button { flex: 1; }.result-toolbar .hint { width: 100%; margin-left: 0; }
}